Preparation method of deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier

The invention discloses a preparation method of a deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier. The method comprises the following steps: preparing a camptothecin prodrug monomer with a trimer structure; preparing acid responsive removable polyethylene glycol with double bonds; preparing a poly prodrug with dual responsiveness and high drug loading capacity; and preparation of the deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier: self-assembling the prepared dual-responsiveness high-drug-loading-capacity poly-prodrug in deionized water to obtain the deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier. The drug loading capacity of the camptothecin drug is greatly improved, in addition, due to the dual responsiveness, controllable release of the camptothecin drug is achieved, the size becomes small after a polyethylene glycol chain is removed, then the combining capacity of the nano-carrier and cells is imp