Peptidomimetic compound as well as preparation method, pharmaceutical composition and application thereof

The invention relates to a peptidomimetic compound as well as a preparation method, a pharmaceutical composition and application thereof. Specifically, the invention discloses a peptidomimetic compound as shown in a general formula (I), or a raceme, a cis-trans-isomer, an enantiomer, a diastereoisomer or a mixture thereof, or a metabolite, or a pharmaceutically acceptable salt, a solvate or a prodrug, the invention also discloses an application of the compound in inhibition of coronaviruses such as SARS-CoV-2, SARS-CoV, MERS-CoV and the like, and other RNA viruses such as EV71, EV68, norovirus and the like. 本发明涉及一种拟肽类化合物及其制备方法、药物组合物和用途。具体地，本发明公开了一种通式(I)所示的拟肽类化合物、或其外消旋体、顺反异构体、对映异构体、非对映异构体或它们的混合物，或其代谢物，或其药学上可接受的盐、溶剂化物或前药；本发明还公开了所述化合物在抑制包括SARS-CoV-2、SARS-CoV、MERS-CoV等冠状病毒，以及其他如EV71、EV68、诺如病毒等RNA病毒方面的应用。