Preparation method and application of S2.2-PEG-MZF-NPs molecular probe

The invention relates to a preparation method and application of an S2.2-PEG-MZF-NPs molecular probe, and belongs to the technical field of breast cancer diagnosis and treatment. The preparation method comprises the following steps: firstly, taking iron nitrate nonahydrate, manganese chloride and zinc chloride as raw materials, preparing manganese zinc ferrite magnetic nanoparticles MZF-NPs by adopting a hydrothermal method, and then modifying the surface of the MZF-NPs by virtue of phospholipid polyethylene glycol maleimide DSPE-PEG-Mal, so as to prepare PEG-MZF-NPs; finally, the Mal group and sulfydryl modified at the tail end of a ligand S2.2 react to prepare the S2.2-PEG-MZF-NPs molecular probe, and the S2.2-PEG-MZF-NPs molecular probe serves as a negative contrast agent to be applied to magnetic resonance imaging or serves as a tumor thermal therapy medium. The invention successfully constructs the S2.2-PEG-MZF-NPs molecular probe, which meets the requirements of medical biological materials, and the mag