Chlorpromazine hydrochloride injection and preparation method thereof
The invention discloses a chlorpromazine hydrochloride injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, each chlorpromazine hydrochloride injection contains 25mg of chlorpromazine hydrochloride, 0.1-0.4 mg of sodium pyrosulfite, 0.1-0.3 m...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a chlorpromazine hydrochloride injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, each chlorpromazine hydrochloride injection contains 25mg of chlorpromazine hydrochloride, 0.1-0.4 mg of sodium pyrosulfite, 0.1-0.3 mg of cysteine, and a phosphate buffer solution with the pH of 5.0 added to 2mL; the preparation method comprises the following steps: taking 60-70wt% of a phosphate buffer solution, dissolving sodium pyrosulfite in the phosphate buffer solution, then adding activated carbon for needles, filtering until the solution is clear, vacuumizing, filling nitrogen, finally adding chlorpromazine hydrochloride and cysteine, stirring for dissolving, adding the remaining phosphate buffer solution, and uniformly mixing; and filtering once by using a filter membrane with the aperture of 0.45 mu m, then filtering twice by using a filter membrane with the aperture of 0.22 mu m, and filling and sealing. The chlorpromazine hydrochlori |
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