Aryl amide derivative with anti-tumor activity

The present disclosure provides, for example, compounds represented by the following general formula (6) [in the formula, X1, X2, X3, and X4 are each independently-CR2 = or-N =, R2 is, for example, a halogen atom, R1 is, for example,-S (= O) 2-NH-R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and n is an integer of 1-3. And R4 is, for example, cyclopropyl] or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of the compound or the salt. The compound, the salt or the solvate provided by the invention has high RAF/MEK complex stable activity, and can be used for treating or preventing cell proliferative diseases, especially cancer. 本公开提供例如由下述通式(6)[式中，X1、X2、X3和X4分别独立地是-CR2＝或-N＝，R2是例如卤素原子，R1是例如-S(＝O)2-NH-R8，R8是例如C1～6烷基，R3是例如氢原子，R5是例如卤素原子，R6是例如氢原子，R4是例如环丙基]表示的化合物或其药学上可接受的盐或前述化合物或盐的药学上可接受的溶剂化物。根据本公开提供的化合物、盐或溶剂化物具有高RAF/MEK复合物稳定活性，能够用于细胞增殖性疾病、特别是癌症的治疗或预防。