LIPID NANOPARTICLE COMPOSITIONS COMPRISING TERMINAL CLOSED DNA AND CLOSABLE LIPIDS AND METHODS OF USING SAME

Provided herein are lipid formulations comprising a lipid and a capsid-free non-viral vector (e.g., ceDNA). The lipid particles (e.g., lipid nanoparticles) of the present invention comprise a lipid formulation that can be used to deliver an uncapsid non-viral DNA vector to a target site of interest (e.g., a cell, tissue, organ, etc. 本文提供了包括脂质和无衣壳非病毒载体(例如，ceDNA)的脂质调配物。本发明的脂质颗粒(例如，脂质纳米颗粒)包含脂质调配物，其可用于将无衣壳非病毒DNA载体递送至所关注的目标位点(例如，细胞、组织、器官等)。