Preparation method of 2-fluoro-3-trifluoromethylaniline

The invention discloses a preparation method of 2-fluoro-3-trifluoromethylaniline, which comprises the following steps: a) dissolving 2, 5-dichlorobenzotrifluoride in a first solvent, adding a nitration reagent, and reacting to obtain 3-nitro-2, 5-dichlorobenzotrifluoride; 3-nitro-2, 5-dichlorobenzo...

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Hauptverfasser: HE BIN, YU CHUANZONG, ZHENG YURONG, CHEN ZHENGWEI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of 2-fluoro-3-trifluoromethylaniline, which comprises the following steps: a) dissolving 2, 5-dichlorobenzotrifluoride in a first solvent, adding a nitration reagent, and reacting to obtain 3-nitro-2, 5-dichlorobenzotrifluoride; 3-nitro-2, 5-dichlorobenzotrifluoride is dissolved in a second solvent, a fluorination reagent is added, and 2-fluoro-3-nitro-5-chlorobenzotrifluoride is obtained through a reaction; and dissolving the 2-fluoro-3-nitro-5-chlorobenzotrifluoride in a third solvent, adding a catalyst and a reducing agent, and reacting to obtain the 2-fluoro-3-trifluoromethylaniline. The total yield of the prepared 2-fluoro-3-trifluoromethylaniline reaches 68% or above, the purity of the 2-fluoro-3-trifluoromethylaniline is 95% or above, the reaction raw materials are low in price and easy to obtain, the reaction operation is simple, the reaction steps are few, and three wastes are few. 本发明公开了一种2-氟-3-三氟甲基苯胺的制备方法,包括:a)将2,5-二氯三氟甲苯溶解于第一溶剂中,加入硝化试剂,反应得到3-硝基-2,5-二氯三氟