Application of rhamnocitrin in preparation of anti-influenza virus drugs

The invention provides application of rhamnocitrin in preparation of anti-influenza virus drugs, and belongs to the technical field of biological medicines. According to the application, rhamnocitrin with non-toxic concentration is selected for application research of anti-influenza virus drugs, pla...

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Hauptverfasser: BI MINGXUAN, HUANG BAOYING, YE FEI, TAN WENJIE, ZHU NA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides application of rhamnocitrin in preparation of anti-influenza virus drugs, and belongs to the technical field of biological medicines. According to the application, rhamnocitrin with non-toxic concentration is selected for application research of anti-influenza virus drugs, plaque inhibition experiments find that the rhamnocitrin can effectively inhibit replication of influenza A virus A/PuertoRadio/8/1934 (H1N1) in vitro, dose effect correlation is shown, IC50 of the A/PuertoRadio/8/1934 (H1N1) influenza virus with MOI equal to 0.0004 dose is 10.59 mu g/ml, and IC50 of the rhamnocitrin is 10.59 mu g/ml, so that the rhamnocitrin can effectively inhibit replication of the influenza A virus A/PuertoRadio/8/1934 (H1N1) influenza virus with the MOI equal to 0.0004 dose. The astragalus smicus glycoside has anti-influenza virus activity, lays a foundation for further development of anti-influenza virus drugs, and has important development value and wide application prospects. 本发明提供了鼠李柠檬素在制备抗流感