Nanometer preparation of nucleic acid aptamer loaded by exosome and aiming at transforming growth factor beta II type receptor and preparation method of nanometer preparation

The invention provides a nano preparation of a nucleic acid aptamer loaded by an exosome and aiming at a transforming growth factor beta II type receptor and a preparation method of the nano preparation. The nucleic acid aptamer nano preparation is a hollow hemispherical particle which is composed of an exosome and a nucleic acid aptamer and is of a double-layer membrane structure, and the nucleic acid aptamer is loaded on the exosome; the particle size of the nucleic acid aptamer nano preparation is 30 to 150 nm; the nucleic acid aptamer is Seq58. The invention also provides a preparation method of the nucleic acid aptamer nano preparation. The nucleic acid aptamer nano preparation aiming at the transforming growth factor beta II type receptor can competitively inhibit the combination of TGF-beta and the receptor Tbeta R II thereof, has good biological safety, immunogenicity and long-circulation half-life period, can be applied to inhibition of fibroblast proliferation and transdifferentiation after glaucoma