Ionizable lipid as well as composition and application thereof

The invention discloses an ionizable lipid as well as a composition and application thereof. Belongs to the technical field of medicines, and provides a general formula shown in the formula (1) or pharmaceutically available salts thereof, and the salts mainly comprise long carbon chains, biodegradable ester bonds, biologically reducible disulfide bonds and other structures. The ionizable lipid, the corresponding composition and the nucleic acid can be prepared into lipid nanoparticles with the particle size of about 100 nm; the lipid nanoparticles have efficient lysosome escape ability and transfection efficiency, can significantly silence protein kinase 3 (PKN3) genes related to prostate cancer, and inhibit invasion and metastasis of prostate cancer cells and growth of tumors; the invention has important significance for enriching the types of ionized lipids, delivering gene drugs and preventing or treating gene-related diseases. 本发明公开了一种可离子化脂质、其组合物及应用。属于医药技术领域，本发明提出了式(1)所示的通式，或其药物可用的盐，主要由长碳链，可生物降解的酯键，可生物还原的