Preparation method of bis (aziridinyl) photo-crosslinking probe intermediate and derivative

The preparation method comprises the following steps: dissolving a ligand and a transition metal catalyst in a solvent, carrying out ultrasonic uniform mixing, adding a compound III, a compound II, alkali and a photocatalyst, introducing argon at room temperature for protection, and carrying out an illumination reaction to obtain a compound as shown in a formula I; according to the preparation method of the bis-aziridinyl photo-crosslinking probe intermediate and the derivative provided by the invention, aldehyde and halide are mainly used as main raw materials, and the raw materials have the characteristics of small irritation and easiness in obtaining. According to the method, photocatalytic coupling reaction is utilized at normal temperature and normal pressure, the synthesis steps are simple, the synthesis yield is remarkably improved, inorganic salt is generated except products after the reaction, and the method is small in environmental pollution and environmentally friendly. 本发明公开了一种双吖丙啶基光交联探针中间体及衍生物的制