Application of specific inhibitor of Hedgehog pathway in preparation of medicine for treating intrauterine adhesion

The invention provides an application of a specific inhibitor of a Hedgehog pathway in preparation of a medicine for treating intrauterine adhesion. According to the application disclosed by the invention, tests show that when a Hedgehog pathway inhibitor, namely Vismodegib, is used on an IUA mouse, the activation of a Hedgehog pathway in uterine tissues of the IUA mouse can be obviously inhibited, meanwhile, the occurrence of endometrial fibrosis is inhibited, and the receptivity of endometrium and the implantation rate/pregnancy rate of the IUA mouse are obviously improved. Moderate and severe intrauterine adhesion relapses repeatedly after clinical treatment, the relapse rate is high, and no effective treatment method exists at present. Therefore, the Hedgehog pathway inhibitor, namely the Vismodegib, provides a novel treatment medicine for the clinical treatment of the IUA patient. 本发明提供了Hedgehog通路的特异性抑制剂在制备用于治疗宫腔粘连的药物中的应用。本发明经过试验发现在IUA小鼠上使用Hedgehog通路抑制剂-维莫德吉(Vismodegib)，可以明显抑制IUA小鼠子宫组织中Hedgehog通路的激活，同时抑制