Application of novel SRSF1 shearing factor small-molecule inhibitor Okanin and pharmaceutical composition of novel SRSF1 shearing factor small-molecule inhibitor Okanin

The invention discloses application of a novel SRSF1 shearing factor small-molecule inhibitor Okanin and a pharmaceutical composition of the novel SRSF1 shearing factor small-molecule inhibitor Okanin, the pharmaceutical composition comprises active ingredients, and the active ingredients comprise the SRSF1 shearing factor small-molecule inhibitor Okanin and an immune checkpoint inhibitor alphaPD-1; the direct action target of the Okanin is the RNA binding core region of the SRSF1 protein, and the SRSF1 is prevented from playing a downstream glycolysis promoting function, so that the tumor cell proliferation is inhibited. Meanwhile, Okanin can act on CD8 + T cells, and the effector function of the CD8 + T cells is enhanced, so that the tumor cell killing activity of the Okanin is improved. 本发明公开了新型SRSF1剪切因子小分子抑制剂Okanin的应用及其药物组合，所述药物组合物包括活性成分，所述活性成分包括SRSF1剪切因子小分子抑制剂Okanin与免疫检查点抑制剂αPD-1；Okanin直接作用靶点为SRSF1蛋白的RNA结合核心区域，阻止SRSF1发挥下游促糖酵解功能，从而抑制肿瘤细胞增殖。同时Okanin可作用于CD8+T细胞，增强CD8+T细胞的效应功能从而提高其杀伤肿瘤细胞的活性。