Boron-nitrogen internal coordination borate hydrogel and preparation method thereof

The invention relates to a preparation method of boron-nitrogen internal coordination borate hydrogel, which comprises the following steps: blending phenylboronic acid molecule-containing aqueous solution and N, N-bis (2-hydroxyethyl) molecule-containing aqueous solution, and adjusting the pH value to 2-11 until the solution is gelatinized to obtain the boron-nitrogen internal coordination borate hydrogel. The preparation method is simple, other toxic catalysts do not need to be added, and the obtained hydrogel has multiple pH corresponding intervals, and meanwhile has glucose and active oxygen responsiveness, injectability and good biocompatibility. 本发明涉及一种硼氮内配位硼酸酯水凝胶的制备方法，将含苯硼酸分子水溶液与含N,N-双(2-羟乙基)分子水溶液中共混，调节pH至2～11，至溶液成胶，得到硼氮内配位硼酸酯水凝胶。所述制备方法简单，不需要添加其他有毒催化剂，所得水凝胶具有多重pH相应区间，同时具有葡萄糖、活性氧响应性以及可注射和良好的生物相容性。