Chimeric antigen receptors and uses thereof

Chimeric antigen receptors and uses thereof are provided. The present invention relates to chimeric antigen receptors (CARs) directed against cells expressing dysfunctional or non-functional P2X purine receptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumors express...

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Bibliographische Detailangaben
Hauptverfasser:	SADLON TIMOTHY JOHN, BARRY SIMON C, COOMBS JUSTIN T
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Chimeric antigen receptors and uses thereof are provided. The present invention relates to chimeric antigen receptors (CARs) directed against cells expressing dysfunctional or non-functional P2X purine receptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumors expressing dysfunctional or non-functional P2X purine receptor 7 receptor, as well as methods of treating and preventing cancer in a subject. 提供了嵌合抗原受体及其用途。本发明涉及针对表达功能失调或非功能性P2X嘌呤受体7受体的细胞的嵌合抗原受体(CAR)。进一步提供了靶向表达功能失调或非功能性P2X嘌呤受体7受体的赘生性细胞和肿瘤的方法，以及治疗和预防受试者中的癌症的方法。