Refining method of cefotaxime sodium

The invention discloses a refining method of cefotaxime sodium, which comprises the following steps: (1) dissolving cefotaxime acid in a mixed solvent of water, methanol and acetone, adding sodium acetate, and stirring to dissolve and clarify; (2) adding activated carbon, stirring, and then filtering; (3) quickly adding ethyl acetate into the filtrate under strong turbulence; the Reynolds number of the intense turbulence is more than 11000; (4) growing crystals under moderate turbulent flow; the mitigated turbulent flow is that the Reynolds number reaches 4000 to 6000; (5) ethyl acetate is slowly added under rapid turbulence, crystal growing is continued, and the rapid turbulence is that the Reynolds number reaches 6500-8000; and (6) after crystal growing is finished, filtering, washing and drying in vacuum to obtain the cefotaxime sodium. According to the invention, rapid turbulence crystallization is adopted, and various solvents are adopted, so that the solubility of different impurities can be increased,