Benzodihydropyran compound with anti-hepatitis B virus and anti-coronavirus effect

The invention relates to a benzodihydropyran compound with effects of resisting hepatitis B virus and coronavirus, especially SARS-CoV-2, and a preparation method and application of the benzodihydropyran compound. Specifically, the invention provides a preparation method and application of a compound as shown in a formula I. The compound is used for preventing, treating or relieving hepatitis B virus infectious diseases and coronavirus infectious diseases. The compound disclosed by the invention has relatively strong activity of resisting hepatitis B virus and coronavirus, especially SARS-CoV-2, and is used as an active component to be prepared into a medicine or a medicine composition for resisting hepatitis B virus or coronavirus together with a pharmaceutically acceptable carrier or auxiliary materials. 本发明涉及具有抗乙肝病毒和冠状病毒特别是SARS-CoV-2作用的苯并二氢吡喃类化合物及其制备方法和应用。具体而言，本发明提供了一种式I所示的化合物的制备方法及其用途，其用途用于预防、治疗或减轻乙肝病毒感染性疾病和冠状病毒感染性疾病。本发明的化合物具有较强的抗乙肝病毒和冠状病毒特别是SARS-CoV-2活性，用其作为活性成分与药学上可接受的载体或辅料制备成抗乙肝病毒或抗冠状病毒药物或药物组合物。