Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer
The invention relates to the technical field of medicine, in particular to application of TMEM100 in regulation and control of lung cancer 5-fluorouracil drug resistance. Experiments prove that expression of TMEM100 in lung cancer drug-resistant cell strains is reduced; tMEM100 overexpression inhibi...
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creator | YE ZAITING YIN ZHANGYONG CAO ZHUO CAI XIAOPING PAN JIONGWEI XU CUNLAI |
description | The invention relates to the technical field of medicine, in particular to application of TMEM100 in regulation and control of lung cancer 5-fluorouracil drug resistance. Experiments prove that expression of TMEM100 in lung cancer drug-resistant cell strains is reduced; tMEM100 overexpression inhibits the activity of lung cancer drug-resistant cell strains and enhances the sensitivity of cells to 5-FU; the TMEM100 overexpression reduces the proliferation of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU; the overexpression of TMEM100 promotes the apoptosis of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU.
本发明涉及医药技术领域,尤其涉及TMEM100在调控肺癌5-氟尿嘧啶耐药的应用,本发明通过实验证明,TMEM100在肺癌耐药细胞株中表达降低;TMEM100过表达抑制肺癌耐药细胞株的活力,增强细胞对5-FU的敏感性;TMEM100过表达降低了肺癌耐药细胞株的增殖,增强了细胞对5-FU的敏感性;TMEM100过表达促进了肺癌耐药细胞株的凋亡,增强了细胞对5-FU的敏感性。 |
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本发明涉及医药技术领域,尤其涉及TMEM100在调控肺癌5-氟尿嘧啶耐药的应用,本发明通过实验证明,TMEM100在肺癌耐药细胞株中表达降低;TMEM100过表达抑制肺癌耐药细胞株的活力,增强细胞对5-FU的敏感性;TMEM100过表达降低了肺癌耐药细胞株的增殖,增强了细胞对5-FU的敏感性;TMEM100过表达促进了肺癌耐药细胞株的凋亡,增强了细胞对5-FU的敏感性。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220809&DB=EPODOC&CC=CN&NR=114870017A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220809&DB=EPODOC&CC=CN&NR=114870017A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YE ZAITING</creatorcontrib><creatorcontrib>YIN ZHANGYONG</creatorcontrib><creatorcontrib>CAO ZHUO</creatorcontrib><creatorcontrib>CAI XIAOPING</creatorcontrib><creatorcontrib>PAN JIONGWEI</creatorcontrib><creatorcontrib>XU CUNLAI</creatorcontrib><title>Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer</title><description>The invention relates to the technical field of medicine, in particular to application of TMEM100 in regulation and control of lung cancer 5-fluorouracil drug resistance. Experiments prove that expression of TMEM100 in lung cancer drug-resistant cell strains is reduced; tMEM100 overexpression inhibits the activity of lung cancer drug-resistant cell strains and enhances the sensitivity of cells to 5-FU; the TMEM100 overexpression reduces the proliferation of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU; the overexpression of TMEM100 promotes the apoptosis of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU.
本发明涉及医药技术领域,尤其涉及TMEM100在调控肺癌5-氟尿嘧啶耐药的应用,本发明通过实验证明,TMEM100在肺癌耐药细胞株中表达降低;TMEM100过表达抑制肺癌耐药细胞株的活力,增强细胞对5-FU的敏感性;TMEM100过表达降低了肺癌耐药细胞株的增殖,增强了细胞对5-FU的敏感性;TMEM100过表达促进了肺癌耐药细胞株的凋亡,增强了细胞对5-FU的敏感性。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjE0KwjAQRrtxIeodxgMUElTabSkVN3XVfYnpNASGmZCf-9uCB3D18fge71h9uhDIW5O9MMgK0ziMWinwDBFdoe1gB4YXsMI5CtHOj3qlIlFKNNYTLLG4TU8-ZcMW9w6VTbM7xXN1WA0lvPz2VF2fw9S_agwyYwrGImOe-7fW97ZRSjfd7R_nC6jbPQo</recordid><startdate>20220809</startdate><enddate>20220809</enddate><creator>YE ZAITING</creator><creator>YIN ZHANGYONG</creator><creator>CAO ZHUO</creator><creator>CAI XIAOPING</creator><creator>PAN JIONGWEI</creator><creator>XU CUNLAI</creator><scope>EVB</scope></search><sort><creationdate>20220809</creationdate><title>Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer</title><author>YE ZAITING ; YIN ZHANGYONG ; CAO ZHUO ; CAI XIAOPING ; PAN JIONGWEI ; XU CUNLAI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114870017A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YE ZAITING</creatorcontrib><creatorcontrib>YIN ZHANGYONG</creatorcontrib><creatorcontrib>CAO ZHUO</creatorcontrib><creatorcontrib>CAI XIAOPING</creatorcontrib><creatorcontrib>PAN JIONGWEI</creatorcontrib><creatorcontrib>XU CUNLAI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YE ZAITING</au><au>YIN ZHANGYONG</au><au>CAO ZHUO</au><au>CAI XIAOPING</au><au>PAN JIONGWEI</au><au>XU CUNLAI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer</title><date>2022-08-09</date><risdate>2022</risdate><abstract>The invention relates to the technical field of medicine, in particular to application of TMEM100 in regulation and control of lung cancer 5-fluorouracil drug resistance. Experiments prove that expression of TMEM100 in lung cancer drug-resistant cell strains is reduced; tMEM100 overexpression inhibits the activity of lung cancer drug-resistant cell strains and enhances the sensitivity of cells to 5-FU; the TMEM100 overexpression reduces the proliferation of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU; the overexpression of TMEM100 promotes the apoptosis of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU.
本发明涉及医药技术领域,尤其涉及TMEM100在调控肺癌5-氟尿嘧啶耐药的应用,本发明通过实验证明,TMEM100在肺癌耐药细胞株中表达降低;TMEM100过表达抑制肺癌耐药细胞株的活力,增强细胞对5-FU的敏感性;TMEM100过表达降低了肺癌耐药细胞株的增殖,增强了细胞对5-FU的敏感性;TMEM100过表达促进了肺癌耐药细胞株的凋亡,增强了细胞对5-FU的敏感性。</abstract><oa>free_for_read</oa></addata></record> |
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title | Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer |
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