Application of TMEM100 in regulating and controlling 5-fluorouracil drug resistance of lung cancer

The invention relates to the technical field of medicine, in particular to application of TMEM100 in regulation and control of lung cancer 5-fluorouracil drug resistance. Experiments prove that expression of TMEM100 in lung cancer drug-resistant cell strains is reduced; tMEM100 overexpression inhibits the activity of lung cancer drug-resistant cell strains and enhances the sensitivity of cells to 5-FU; the TMEM100 overexpression reduces the proliferation of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU; the overexpression of TMEM100 promotes the apoptosis of lung cancer drug-resistant cell strains, and enhances the sensitivity of cells to 5-FU. 本发明涉及医药技术领域，尤其涉及TMEM100在调控肺癌5-氟尿嘧啶耐药的应用，本发明通过实验证明，TMEM100在肺癌耐药细胞株中表达降低；TMEM100过表达抑制肺癌耐药细胞株的活力，增强细胞对5-FU的敏感性；TMEM100过表达降低了肺癌耐药细胞株的增殖，增强了细胞对5-FU的敏感性；TMEM100过表达促进了肺癌耐药细胞株的凋亡，增强了细胞对5-FU的敏感性。