Clinical and industrial scale complete tissue sequencing

Devices, methods, and systems are provided for in situ gene sequencing of a target nucleic acid in a cell within intact tissue. The invention also provides a method of screening a candidate agent to determine whether the candidate agent is capable of modulating gene expression of a nucleic acid in a cell within intact tissue. 本发明提供了用于对完整组织内细胞中的靶核酸进行原位基因测序的设备、方法和系统。本发明还提供了筛选候选药剂以确定所述候选药剂能否调控完整组织内细胞中核酸的基因表达的方法。