Process for production, recovery and purification of capsular polysaccharide polyribosyl-ribitol-phosphoric acid (PRP) and uses thereof

The present invention relates to methods comprising the production and purification of capsular polysaccharide polyribosylribitol phosphate (PRP) produced by the bacterium Haemophilus influenzae type b (Hib) to obtain polysaccharides of suitable molecular mass and purity for the subsequent formulati...

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Bibliographische Detailangaben
Hauptverfasser:	SIMAS ROBERT G, CABRERA-CRESPO JORGE, BRAGA, LUIS, G, TAKACS, M ¨ ¢ RTON, ALBANI SYLVAIN MARIE FRANCOIS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to methods comprising the production and purification of capsular polysaccharide polyribosylribitol phosphate (PRP) produced by the bacterium Haemophilus influenzae type b (Hib) to obtain polysaccharides of suitable molecular mass and purity for the subsequent formulation of Hib conjugate vaccines. The invention also relates to an application of the capsular polysaccharide polyribosyl ribitol phosphate (PRP) in preparation of vaccines. 本发明涉及包括生产和纯化由细菌b型流感嗜血杆菌(Hib)产生的荚膜多糖聚核糖基核糖醇磷酸(PRP)的方法，以获得具有合适分子质量和纯度的多糖，用于随后配制Hib结合疫苗。本发明还涉及荚膜多糖聚核糖基核糖醇磷酸(PRP)在制备疫苗中的用途。