Anti-tumor compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical medicines, and particularly relates to an anti-tumor compound as well as a preparation method and application thereof. The invention provides a glycosyl compound as shown in a formula I or a stereoisomer thereof. Biological experiments show th...

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1. Verfasser: JIN ZEMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of chemical medicines, and particularly relates to an anti-tumor compound as well as a preparation method and application thereof. The invention provides a glycosyl compound as shown in a formula I or a stereoisomer thereof. Biological experiments show that the compound is transferred into cells from a glucose receptor and is decomposed in cancer cells to release dichloroacetic acid monomers, the concentration of dichloroacetic acid in the cancer cells is increased, the treatment effect on the cancer cells is improved, meanwhile, the specificity and selectivity of the compound relative to normal cell membranes are reduced, and the treatment effect on the cancer cells is improved. And toxic and side effects of dichloroacetic acid on normal cells are reduced, so that the compound finally becomes a safe, effective and broad-spectrum antitumor drug, and can play a more obvious therapeutic effect on malignant tumors. 本发明属于化学医药技术领域,具体涉及抗肿瘤化合物及其制备方法和用途。本发明提供如式Ⅰ所示的糖基化合物或其立