Ferrocene and camphorsulfonic acid composite derivative, preparation method thereof and application of ferrocene and camphorsulfonic acid composite derivative in catalysis of asymmetric P-S reaction

The invention provides a ferrocene and camphorsulfonic acid composite derivative, a preparation method thereof and application of the ferrocene and camphorsulfonic acid composite derivative in catalysis of asymmetric P-S reaction, and belongs to the technical field of preparation of tetrahydroindolinone spiro compounds. According to the specific application method, tryptamine derivatives and isatin compounds serve as substrates, ferrocene and camphorsulfonic acid composite derivatives serve as catalysts, cyclization reaction is carried out in an organic solvent A at the temperature of 0-100 DEG C, the tetrahydroindolinone spiro compounds are prepared, the yield ranges from 60% to 99%, and the ee value ranges from 85% to 92%. Compared with the prior art, the method has the advantages that the ferrocene and camphorsulfonic acid composite derivative is used as the catalyst for promoting the asymmetric Pictet-Spengler reaction for the first time, the ee value of the tetrahydroindolinone spiro compound is remarkab