Synthesis method of sulfonyl coumarin compound
The invention discloses a synthesis method of a sulfonyl coumarin compound, which belongs to the technical field of chemical synthesis, and comprises the following operation steps: firstly, putting potassium fluoride into a reaction bottle filled with dry DMF (Dimethyl Formamide), then sequentially...
Gespeichert in:
Hauptverfasser: | , , , , , , |
---|---|
Format: | Patent |
Sprache: | chi ; eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The invention discloses a synthesis method of a sulfonyl coumarin compound, which belongs to the technical field of chemical synthesis, and comprises the following operation steps: firstly, putting potassium fluoride into a reaction bottle filled with dry DMF (Dimethyl Formamide), then sequentially adding beta-ketone sulfonyl fluoride and an aromatic compound, heating for reaction, and after the reaction is monitored by TLC (Thin Layer Chromatography), filtering, washing and drying to obtain the sulfonyl coumarin compound. Quenching the mixture with deionized water, extracting with ethyl acetate, collecting an organic phase, drying the organic phase with anhydrous sodium sulfate, removing a solvent through a rotary evaporator, adding a sample into a separation column in a dry-method sample loading manner, and performing silica gel column chromatography separation to obtain a target product; the invention provides a simple and mild-condition new way for synthesizing the sulfonyl coumarin derivative, and overco |
---|