2, 6-dibenzylidene cyclohexanone oxime compound as well as preparation method and application thereof

The invention belongs to the technical field of anti-inflammatory drugs, and discloses a 2, 6-dibenzylidene cyclohexanone oxime compound as well as a preparation method and application thereof. A structural fragment with anti-inflammatory activity is introduced into the 2, 6-dibenzylidene cyclohexanone oxime compound, and the prepared compound is stable in physicochemical property. Experiments show that the 2, 6-dibenzylidene cyclohexanone oxime compound has an excellent inhibitory effect on inflammatory factors and better in-vivo anti-inflammatory activity, especially has a protective effect on hepatitis and fatty liver caused by expression and release of TNF-alpha and/or IL-6 exceeding normal quantity, and also has a protective effect on liver inflammation and dirty lipid metabolism. 本发明属于抗炎药物技术领域，公开了一种2,6-二苯亚甲基环己酮肟类化合物及其制备方法和应用。本发明在2,6-二苯亚甲基环己酮肟类化合物中引入了具有抗炎活性的结构片段，制得的化合物理化性质稳定。实验表明2,6-二苯亚甲基环己酮肟类化合物具有优秀的炎症因子的抑制作用以及更好的体内抗炎活性，尤其是对于由TNF-α和/或IL-6超出正常量表达和释放而导致的肝炎和脂肪肝，而且对肝脏炎症以及脏脂质代谢具有保护作用。