Sulfonylbenzamide derivatives as BCL-2 inhibitors

The present disclosure relates to sulfonyl benzamide derivatives as BCL-2 inhibitors. The present disclosure provides compounds of Formula I, and pharmaceutically acceptable salts and solvates thereof, wherein the variables are defined as described in the specification. The disclosure also provides a compound of Formula I for use in the treatment of a disease, disorder or condition responsive to the inhibition of Bcl-2 protein, in particular Bcl-2 WT and/or Bcl-2 G101V. 本公开涉及作为BCL-2抑制剂的磺酰基苯甲酰胺衍生物。本公开提供了具有式I的化合物及其药学上可接受的盐和溶剂化物，其中变量如说明书中所述定义。本公开还提供了式I的化合物，该化合物用于治疗对Bcl-2蛋白，特别是Bcl-2 WT和/或Bcl-2 G101V的抑制有响应的疾病、病症或病况。