Stable anti-EGFR antibody composition

The invention relates to a stable pharmaceutical composition capable of specifically binding to EGFR (epidermal growth factor receptor) protein. Specifically, the invention relates to a pharmaceutical composition, which comprises a histidine/histidine hydrochloride buffer agent, an anti-EGFR antibod...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WU CHONGBING, ZHU CAILIN, MA YUN, DU WUCHEN, GAO CHAO, SHEN WEIQIANG, JIANG XIAOLING
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a stable pharmaceutical composition capable of specifically binding to EGFR (epidermal growth factor receptor) protein. Specifically, the invention relates to a pharmaceutical composition, which comprises a histidine/histidine hydrochloride buffer agent, an anti-EGFR antibody or an antigen binding fragment thereof, polysorbate 80 and trehalose. The pharmaceutical composition disclosed by the invention still shows relatively high antibody stability after being stored for several months. 本发明涉及一种可特异性结合EGFR蛋白的稳定的药物组合物。具体而言,本发明涉及一种药物组合物,包含组氨酸/盐酸组氨酸缓冲剂、含有抗EGFR抗体或其抗原结合片段、聚山梨酯80和海藻糖。本发明中的药物组合物在储存数月之后依然显示出较高的抗体稳定性。