Triptolide solid lipid nanoparticle and preparation method of triptolide solid lipid nanoparticle dropping pill

The invention discloses a triptolide solid lipid nanoparticle dropping pill, which is prepared from the following raw material components in percentage by weight: 1.2% of wool fat, 0.2% of stearic acid, 1.15% of poloxamer188, 2.25% of glycerol, 0.01-0.1% of triptolide and the balance of water and an equal amount of aqueous solution containing 10wt% of chitosan-acetylcysteine conjugate with low relative molecular mass. According to the method, a triptolide solid nanoparticle suspension modified by chitosan-acetylcysteine with low relative molecular mass is rapidly cooled and centrifuged, and the solid liposome nanoparticles are obtained. And mixing the solid lipidosome nanoparticle suspension with a PEG6000 matrix according to a mass ratio of 3: 7 to prepare the dropping pill, so as to obtain the triptolide solid lipid nanoparticle dropping pill. The preparation method disclosed by the invention is simple and easy to operate, and the bioavailability of the triptolide is high. 本发明公开了一种雷公藤内酯醇固体脂质纳米粒滴丸，按重量分数计，包含以