Blood coagulant as well as preparation method and application thereof

The invention relates to the technical field of biological materials, and particularly discloses a blood coagulant as well as a preparation method and application thereof. The blood coagulant is prepared from nano silicon dioxide, a vinyl pyrrolidone-vinyl acetate copolymer, polyethylene glycol stearate and a solvent, wherein the mass ratio of the nano silicon dioxide to the vinyl pyrrolidone-vinyl acetate copolymer to the polyethylene glycol stearate is (1-5): 1: (1-10). The blood coagulant prepared by the invention is short in coagulation time, and the obtained serum is high in quality; irradiation sterilization can be performed, and the performance of a product subjected to irradiation sterilization, aging and other treatments is equivalent to that of a product before treatment; the product performance is not influenced while the validity period is prolonged to 1 year, and the phenomena of sedimentation and caking are avoided in the storage process; the clinical detection requirements can be met. 本发明涉及生物材料