Application of biological preparation in treatment of placenta dysfunction

The invention aims to provide application of a biological preparation in treatment of placenta dysfunction, and belongs to the technical field of medicine. The biological agent is composed of siRNA for inhibiting expression of the LOC101929800 gene, the transcript sequence of the LOC101929800 gene is shown as SEQ ID NO.1 in a sequence table, and the sequences of the siRNA are shown as SEQ ID NO.10 and SEQ ID NO.11 in the sequence table. SiRNA is transfected in hypoxia reoxygenation cells to inhibit the LOC101929800 gene, it is found that the LOC101929800 gene can reverse reduction of the invasion ability of trophoblast cells caused by hypoxia reoxygenation to a certain degree, and therefore the LOC101929800 gene can be used for preparing a biological preparation for treating placenta injury. 本发明的目的在于提供一种生物制剂在治疗胎盘功能障碍中的应用，属于医学技术领域。该生物制剂由抑制LOC101929800基因表达的siRNA组成，LOC101929800基因的转录本序列为序列表中的SEQ ID NO.1，siRNA的序列为序列表中的SEQ ID NO.10和SEQ ID NO.11。通过在缺氧复氧的细胞中转染siRNA抑制LOC101929800基因，本发明发现其能够一定程度的逆转缺氧复氧所导致的滋养层细胞侵袭能力下降，因