Composition for gene editing and application thereof

The invention provides a composition for gene editing and application thereof, and particularly discloses a target sequence specifically combined with gRNA (guide ribonucleic acid), a gene editing system containing the gRNA, and a composition and a kit containing the gene editing system. According t...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG LINJIE, DU BING, LIU MINGYAO, XI ZAIXI, ZHANG JIQIN, TIAN YUE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a composition for gene editing and application thereof, and particularly discloses a target sequence specifically combined with gRNA (guide ribonucleic acid), a gene editing system containing the gRNA, and a composition and a kit containing the gene editing system. According to the gene editing system, the knockout rate and the recombination rate can be remarkably increased, and the composition and the medicine box can also be used for treating diseases. 本发明提供了用于基因编辑的组合物及其应用，具体地，本发明公开了一种特异性结合gRNA的靶序列，以及含有该gRNA的基因编辑系统，并且本发明还提供了含有该基因编辑系统的组合物和药盒。本发明的该基因编辑系统可显著提高敲除率和重组率，并且本发明的组合物和药盒还可治疗疾病。