Immune cytokines based on IL-15 and IL-15R [alpha] SUSHI domains

The present invention relates to immune cytokines based on the IL-15 and IL-15R [alpha] SUSHI domains. The immunocytokine of the invention comprises (a) a conjugate, and (b) an antibody or a fragment of said antibody directly or indirectly covalently linked to said conjugate wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of interleukin 15 or a derivative thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of IL-15R [alpha] or of a derivative of the sushi domain of IL-15R [alpha]. 本发明涉及基于IL-15和IL-15RαSUSHI结构域的免疫细胞因子。本发明的免疫细胞因子包括(a)缀合物，和(b)直接地或间接地共价连接至所述缀合物的抗体或所述抗体的片段，其中所述缀合物包括(i)包括白细胞介素15或其衍生物的氨基酸序列的多肽，和包括IL-15Rα的sushi结构域或所述IL-15Rα的sushi结构域的衍生物的氨基酸序列的多肽。