N-phenyl alkoxy dibenzazepine compound as well as preparation method and medical application thereof

The invention discloses an N-phenyl alkoxy dibenzazepine compound as well as a preparation method and medical application thereof, belongs to the field of biological medicines, and particularly relates to an N-phenyl alkoxy dibenzazepine compound as shown in a general formula I or pharmaceutically acceptable salt thereof. Pharmacological experiment results show that the compound has excellent P-glycoprotein inhibitory activity, tumor multidrug resistance reversal activity and anti-tumor metastasis activity, and can be clinically used as a tumor multidrug resistance reversal agent and a tumor metastasis inhibitor. 本发明公开了一种N-苯基烷氧基二苯并吖庚因化合物、其制备方法及医药用途，属于生物医药领域，其具体为通式I所示的N-苯基烷氧基二苯并吖庚因化合物或其药学上可接受的盐。药理实验结果表明，本发明化合物具有优良的P-糖蛋白抑制活性、肿瘤多药耐药逆转活性及抗肿瘤转移活性，临床上可作为肿瘤多药耐药逆转剂及肿瘤转移抑制剂应用。