Application of CNPY3 protein as target for treating dengue fever

The invention belongs to the technical field of antiviral drugs, and particularly relates to application of CNPY3 protein as a target spot for treating dengue fever. The invention discloses and identifies an important host protein CNPY3 related to dengue virus infection. The host gene is significantly down-regulated in blood of a dengue patient and in dengue virus infected dendritic cells and THP-1 cells. The expression of the gene is in negative correlation with the dengue disease progress, and is in positive correlation with the expression of most Toll-like receptors. Further research shows that down-regulation of the gene in THP-1 cells inhibits generation of IFN-beta and expression of the ISGs gene and promotes infection of DENV-2. And the expression of the gene is up-regulated in Vero and HEK 293T cells, so that the infection of DENV-2 can be inhibited. The results show that the CNPY3 participates in an innate immune response signal pathway, has an anti-dengue virus effect, and is a potential therapeutic