Gemcitabine hydrochloride chitosan micelle and preparation method thereof

The invention discloses a gemcitabine hydrochloride chitosan micelle and a preparation method thereof, the micelle comprises gemcitabine hydrochloride and chitosan-deoxycholic acid, the molecular weight of the chitosan is 2-40kD, the weight part ratio of the gemcitabine hydrochloride to the chitosan-deoxycholic acid is 1: (5-50), and the gemcitabine hydrochloride chitosan micelle comprises gemcitabine hydrochloride and chitosan-deoxycholic acid. Gemcitabine hydrochloride is effectively loaded through the chitosan-deoxycholic acid micelle drug carrier, the drug loading capacity is improved, the impurity content in the product is reduced, meanwhile, the product stability is enhanced, and the inhibition effect of gemcitabine hydrochloride on cancer cells is remarkably improved. 本发明公开了一种盐酸吉西他滨壳聚糖胶束及其制备方法，所述胶束包含盐酸吉西他滨与壳聚糖-脱氧胆酸，所述壳聚糖分子量为2kD～40kD，其中盐酸吉西他滨与壳聚糖-脱氧胆酸的重量份之比为1:5-50，本发明通过壳聚糖-脱氧胆酸胶束载药体将盐酸吉西他滨有效负载，提升载药量，降低产品中杂质含量，同时增强产品稳定性，显著提升盐酸吉西他滨对癌症细胞的抑制效果。