Bispecific antibodies specific for PD1 and TIM3

The present invention relates to bispecific antibodies specific for PD1 and TIM3. The present invention relates to a bispecific antibody comprising a first antigen binding site that specifically binds to PD1 and a second antigen binding site that specifically binds to TIM3, in particular a bispecifi...

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Bibliographische Detailangaben
Hauptverfasser:	LEVITSKY VIKTOR, CODARRI-DEAK LAURA, FISCHER, JU RG, LIEFKE VOLKER, PEROT, MARC, SCHLOTHAUER TILMAN, FERTIG, GEORG, REGULA JOERG THOMAS, WUENSCH ILDIKO, KLEIN CHRISTIAN, UMANA PABLO, SEEBER STEFAN, ZWICK ADRIAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to bispecific antibodies specific for PD1 and TIM3. The present invention relates to a bispecific antibody comprising a first antigen binding site that specifically binds to PD1 and a second antigen binding site that specifically binds to TIM3, in particular a bispecific antibody wherein the bispecific antibody binds to TIM3 with a lower binding affinity compared to the binding to PD1. The invention further relates to methods of producing these molecules and methods of using them. 本发明涉及对PD1和TIM3特异性的双特异性抗体。本发明涉及包含特异性结合PD1的第一抗原结合位点和特异性结合TIM3的第二抗原结合位点的双特异性抗体，特别是如下的双特异性抗体，其中该双特异性抗体以与对PD1的结合相比要低的结合亲和力结合TIM3。本发明进一步涉及生成这些分子的方法和使用它们的方法。