Clopidogrel hydrogen sulfate tablet and preparation method thereof

The invention provides a preparation method of a clopidogrel hydrogen sulfate tablet. The preparation method of the clopidogrel hydrogen sulfate tablet comprises the following steps: mixing clopidogrel hydrogen sulfate powder with first superfine silica powder to form clopidogrel hydrogen sulfate premixed particles, and then mixing the clopidogrel hydrogen sulfate premixed particles with a diluent to obtain premixed liquid medicine; adding an alcoholic solution of an adhesive into the premixed liquid medicine, and carrying out wet granulation operation to obtain clopidogrel hydrogen sulfate wet granules; adding talcum powder into the clopidogrel hydrogen sulfate wet particles, and then drying and finishing the clopidogrel hydrogen sulfate wet particles to obtain clopidogrel hydrogen sulfate dry particles; mixing the clopidogrel hydrogen sulfate dry particles with a lubricant and a disintegrating agent to obtain a pre-pressed mixture; and tabletting the pre-pressed mixture to obtain the clopidogrel hydrogen su