Compound capable of inducing macrovesicular death of cells as well as preparation method and application of compound

The invention discloses a compound capable of inducing macrovesicular death of cells as well as a preparation method and application of the compound, and the compound is 2-chloro-N-(4-(pyrazol [1, 5-a] pyrimidine-6-yl) phenyl) acetamide. The 2-chloro-N-(4-(pyrazol [1, 5-a] pyrimidine-6-yl) phenyl) acetamide disclosed by the invention has an effect of inducing tumor cell death, and the cell death is caused by formation of a plurality of huge vacuoles in cells induced by the compound, and is called huge bubble type death. The compound has high clinical application value and good development prospect, and can be used for treating tumor diseases. The preparation method is simple and suitable for large-scale synthesis of the compound. 本发明公开了一种可诱导细胞巨泡式死亡的化合物及其制备方法和应用，该化合物为2-氯-N-(4-(吡唑[1,5-a]嘧啶-6-基)苯基)乙酰胺。本发明的2-氯-N-(4-(吡唑[1,5-a]嘧啶-6-基)苯基)乙酰胺具有诱导肿瘤细胞死亡的作用，这种细胞死亡是由该化合物诱导细胞内形成许多巨大空泡导致，称之为巨泡式死亡。该化合物具有较高的临床应用价值和良好的开发前景，可用于肿瘤疾病的治疗。本发明的制备方法简便且适合大量合成该化合物。