Chitosan-based efficient hemostatic with Janus structure as well as preparation method and application of chitosan-based efficient hemostatic

The invention discloses a chitosan-based high-efficiency composite hemostatic with a Janus structure, and belongs to the technical field of biomedical materials, the chitosan-based high-efficiency composite hemostatic mainly comprises methacrylic anhydride, chitosan, calcium carbonate and protonated...

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Hauptverfasser: YU QIAO, ZHANG ZHUYUN, CHANG KAIXI, DENG NINGYUE, QIN ZHENG, ZHAO WEIFENG, YANG QINBO, CHEN SHANSHAN, SU BAIHAI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a chitosan-based high-efficiency composite hemostatic with a Janus structure, and belongs to the technical field of biomedical materials, the chitosan-based high-efficiency composite hemostatic mainly comprises methacrylic anhydride, chitosan, calcium carbonate and protonated acid salt, and the hemostatic is prepared by the following method: preparing methacrylic acid chitosan; the preparation method comprises the following steps: mixing modified chitosan with calcium carbonate, a photoinitiator and the like, dropwise adding the mixture into a carboxylated chitosan aqueous solution to form hydrogel microspheres with a shell structure, and carrying out photo-crosslinking, ion exchange, freeze drying and other methods to obtain Janus chitosan/calcium carbonate particles. And then mixing with protonated acid salt powder to obtain the chitosan-based efficient hemostatic with directional propulsion and a Janus structure. The high-efficiency composite hemostatic has the effects of driving pr