Aza-quinoline compounds and uses thereof

Aza-quinoline compounds and uses thereof

The invention disclosed herein relates to aza-quinoline compounds of formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for the treatment of diseases or conditions mediated by Zeste homolog enhancer 2 (EZH2), Polycomb Suppression Complex 2 (PRC2), or a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DOERR MIKE, MAI XINGYANG, ZHANG JIYUE, MI YUAN, ZHAO KEHAO, GU XIANGJU, QI WEI, OUYANG KONGDE, DAI XUAN, PAPILLON JULIEN, LI LING, YAN XIAOXIA, LIU KANGZHI, YU ZHENGTIAN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention disclosed herein relates to aza-quinoline compounds of formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for the treatment of diseases or conditions mediated by Zeste homolog enhancer 2 (EZH2), Polycomb Suppression Complex 2 (PRC2), or a combination thereof. 本文公开的发明涉及式(I)的氮杂-喹啉化合物，包含此类化合物的药物组合物；以及此类化合物用于治疗由Zeste同源物增强子2(EZH2)、多梳抑制复合体2(PRC2)或其组合介导的疾病或病症的用途。