Compositions and methods comprising anti-NRP2 antibodies

Provided herein are affinity mature and humanized antibodies and antigen binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate the binding interaction between human NRP2 and at least one NRP2 ligand and thereby modulate a subsequent NRP2-mediated downstream signaling event, included are related therapeutic compositions and methods for modulating NRP2 activity and treating diseases, such as NRP2-related diseases. 本文提供了特异性结合人神经纤毛蛋白-2(NRP2)多肽的亲和力成熟的和人源化的抗体及其抗原结合片段，包括调节人NRP2和至少一种NRP2配体之间的结合相互作用并由此调节随后的NRP2介导的下游信号传导事件的那些，包括用于调节NRP2活性和治疗疾病如NRP2相关疾病的相关治疗组合物和方法。