Method and system for efficiently constructing human protein complex map

The invention provides a method and system for efficiently constructing a human protein complex map, and the method comprises the steps: carrying out the edge addition of an initial human protein interaction network, and obtaining a reconstructed human protein interaction network: calculating the fe...

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Hauptverfasser: ZHANG YICHAO, LEE MOON-KEUN, ZHOU SHUIGENG, GUAN HONG, PAN YULIANG, LYU ZHENGHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a method and system for efficiently constructing a human protein complex map, and the method comprises the steps: carrying out the edge addition of an initial human protein interaction network, and obtaining a reconstructed human protein interaction network: calculating the feature attribute of each edge in the reconstructed human protein interaction network; according to the feature attributes of the edges and the reconstructed human protein interaction network, predicting an edge category through a pre-trained edge classification model; based on the edge category and the reconstructed human protein interaction network, utilizing a preset graph segmentation algorithm to identify and obtain a human protein complex; and filtering the human protein complex to obtain the filtered human protein complex as a final human protein complex, and constructing a human protein complex map based on the final human protein complex. According to the method, the compound recognition precision and the co