GLP-1 receptor agonists and uses thereof

Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they exhibit excellent glucose tolerance as GLP-1 receptor agonists, and thus have great potential for use as therapeutic agents for metabolic diseases. In addition, it also shows excellent pharmacological safety to the cardiovascular system. 本发明公开了化学式1的新型化合物、所述化合物的光学异构体、以及所述化合物或所述光学异构体的药学上可接受的盐。所述化合物、异构体及盐展现出作为GLP-1受体激动剂的极佳活性。特别地，其作为GLP-1受体激动剂展现出极佳葡萄糖耐受性，因此具有用作代谢疾病的治疗剂的巨大潜力。此外，其对心血管系统也展现出极佳药理学安全性。