Triphenylene derivatives for imaging biological tissues and fluids

A composition for imaging a biological tissue or fluid comprising a compound of formula (A) wherein X represents one of a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom or a selenium atom and a biologically acceptable diluent or carrier; r represents an aromatic group and/or an alip...

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Bibliographische Detailangaben
Hauptverfasser: PREECE JON, ROBINSON ALEX, IQBAL PARVEZ, JONES OWAIN, BUTLIN MICHAEL, SUND, SARMINE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:A composition for imaging a biological tissue or fluid comprising a compound of formula (A) wherein X represents one of a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom or a selenium atom and a biologically acceptable diluent or carrier; r represents an aromatic group and/or an aliphatic group; p is an integer from 1 to 2; q and s are independently integers of 1, 2, 3 or 4; y1, Y2, and Y3 independently represent a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a polyglycol group, an oxygen atom, a nitrogen atom, a cyano group, or a nitro group; and/or wherein two or more of Y1, Y2, and Y3 may be combined together to form a fused ring. 一种用于使生物组织或流体成像的组合物,其包含式(A)的化合物和生物学上可接受的稀释剂或载体,其中X表示氮原子、氧原子、硫原子、磷原子或硒原子中的一种;R表示芳族基团和/或脂族基团;p是1至2的整数;q和s独立地是1、2、3或4的整数;Y1、Y2和Y3独立地表示氢原子、氘原子、氟原子、氯原子、溴原子、取代或未取代的烷基基团、取代或未取代的芳基基团、聚二醇基团、氧原子、氮原子、氰基基团、硝基基团;和/或其中Y1、Y2和Y3中的两个或更多个可以组合在一起形成稠环。