Immunogenic composition against intestinal diseases and method for preparing same

The present disclosure relates to a novel immunogenic monovalent and multivalent polysaccharide-protein conjugate vaccine composition that does not include a polysaccharide selected from the group consisting of Salmonella typhi, Salmonella paratyphi, Salmonella typhimurium, Salmonella typhimurium, Salmonella enteritidis, Salmonella typhimurium, Salmonella paratyphi, Salmonella typhimurium, Salmonella enteritidis and alternative improved processes for polysaccharide fermentation, polysaccharide purification, proteoglycan protein conjugation and stable formulation. The disclosure also relates to methods of inducing an immune response against Salmonella typhimurium and non-Salmonella typhimurium associated diseases in a subject and/or reducing or preventing Salmonella typhimurium and non-Salmonella typhimurium associated diseases in a subject using the compositions disclosed herein. The vaccines elicit bactericidal antibodies and can be used to prevent gastroenteritis, intestinal fever and typhoid. 本公开涉及一种新的免疫原性