Vero cell-adapted enterovirus D68, enterovirus D68 vaccine and use thereof

The present invention provides a vero cell-adapted enterovirus D68, an enterovirus D68 vaccine, and uses thereof, comprising a vero cell-adapted enterovirus D68 vaccine, the vero cells being cultured in a substantially serum-free medium prior to adaptation. Also disclosed are methods of inducing an immune response against enterovirus D68 infection in a subject, the method comprising administering to the subject an effective amount of the vaccine. 本发明提供了适应vero细胞的肠道病毒D68、肠道病毒D68疫苗及其用途，其中包含适应vero细胞的肠道病毒D68的疫苗，在适应之前在基本上不含血清的培养基中培养所述vero细胞。本发明还公开了在受试者中诱导针对肠道病毒D68感染的免疫应答的方法，所述方法包括向所述受试者给药有效量的所述疫苗。