5, 6-dihydro-1, 2, 4-triazine compound and pharmaceutical application thereof as GLP-1 receptor agonist

The present invention discloses a 5, 6-dihydro-1, 2, 4-triazine compound and a pharmaceutical use thereof as a GLP-1 receptor agonist, the structure of the 5, 6-dihydro-1, 2, 4-triazine compound is as shown in formula I, and in the formula, the definition of each substituent group is as described in...

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Hauptverfasser: YUN YING, LI JING, WANG KAI, SHEN JIANHUA, XU TIFEI, XIE XIN, CHEN LILI, GUO SHIMENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention discloses a 5, 6-dihydro-1, 2, 4-triazine compound and a pharmaceutical use thereof as a GLP-1 receptor agonist, the structure of the 5, 6-dihydro-1, 2, 4-triazine compound is as shown in formula I, and in the formula, the definition of each substituent group is as described in the specification and claims. As a GLP-1 receptor agonist, the compound provided by the invention can be used for treating diabetes mellitus, metabolic syndrome and the like. 本发明公开了一种5,6-二氢-1,2,4-三嗪类化合物及其作为GLP-1受体激动剂的药学用途,5,6-二氢-1,2,4-三嗪类化合物的结构如式I所示,式中,各取代基的定义如说明书和权利要求书中所述。本发明的化合物,作为GLP-1受体激动剂,能够用于治疗糖尿病及代谢综合征等。