Method for controlling release of active ingredients of microspheres

The invention discloses a method for controlling release of active components of microspheres, which comprises the following steps: (1) preparing a test solution from copolymer powder, adding tetrahydrofuran into the copolymer powder, and dissolving to obtain a contrast solution; and (2) detecting the test solution and the contrast solution through high performance liquid chromatography, and calculating to obtain the content of the oligomer in the copolymer, (3) if the content of the oligomer in the copolymer is greater than 10%, refining the copolymer once or multiple times until the content of the oligomer in the copolymer is less than or equal to 10%; and (4) preparing microspheres by taking the obtained copolymer powder with the oligomer content of less than or equal to 10% as a carrier. The preparation method is simple and practical, and by adopting a specific refining method for the copolymer, the oligomer content of the copolymer is effectively controlled to be within a specific range, so that the rele