Synthetic method of fluorophenyl amino acid hydrochloride
The invention discloses a method for synthesizing fluorophenyl amino acid hydrochloride, which comprises the following steps of: 1) carrying out Friedel-Crafts acylation on m-difluorobenzene (compound (I)) serving as an initial raw material and monomethyl oxalate to obtain a compound (II), reacting...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for synthesizing fluorophenyl amino acid hydrochloride, which comprises the following steps of: 1) carrying out Friedel-Crafts acylation on m-difluorobenzene (compound (I)) serving as an initial raw material and monomethyl oxalate to obtain a compound (II), reacting the compound (I) and the monomethyl oxalate at the temperature of between-10 and 50 DEG C under the catalysis of aluminum trichloride, and carrying out post-treatment to obtain the compound (II); 2) reacting the compound (II) with benzylamine in a solvent at 60-110 DEG C, and then performing post-treatment to obtain a compound (III) or a solution thereof; 3) reacting the compound (III) in a solvent under the catalysis of a catalyst at the temperature of 20-100 DEG C and the hydrogen atmosphere of 0-10 MPa, and performing post-treatment to obtain a compound (IV) or a solution thereof; and 4) adding alkali into the compound (IV) or the solution thereof for hydrolysis, performing post-treatment, and salifying with a h |
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