Hybridoma cell strain and application thereof
The invention relates to a hybridoma cell strain and application thereof, and belongs to the field of biomedicine. The hybridoma cell strain disclosed by the invention is t-PAIC2 # and is preserved in China Center for Type Culture Collection on April 18, 2020, the preservation number is CCTCC NO: C2...
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| creator | TAN XIANGUI WU PEITIAN ZHUO YEBIN LYU JINHUA CHEN BO |
| description | The invention relates to a hybridoma cell strain and application thereof, and belongs to the field of biomedicine. The hybridoma cell strain disclosed by the invention is t-PAIC2 # and is preserved in China Center for Type Culture Collection on April 18, 2020, the preservation number is CCTCC NO: C202066, and the preservation address is Wuhan University, Wuhan, China. The invention also provides a tPAI-C monoclonal antibody secreted by the hybridoma cell strain and an application of the tPAI-C monoclonal antibody. The hybridoma cell strain disclosed by the invention can secrete monoclonal antibodies with high affinity to different epitopes of tPAI-C protein; when being used for detecting tPAI-C, the monoclonal antibody disclosed by the invention is not easily interfered by tPA and PAI-1 monomers and is high in accuracy.
本发明涉及一种杂交瘤细胞株及其应用，属于生物医学领域。本发明的杂交瘤细胞株为t-PAIC2#，已于2020年4月18日保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO：C202066，保藏地址为中国武汉，武汉大学。本发明还提供了由该杂交瘤细胞株分泌的tPAI-C单克隆抗体及tPAI-C单克隆抗体的应用。本发明杂交瘤细胞株可分泌对tPAI-C蛋白不同表位具有高亲和力的单克隆抗 |
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本发明涉及一种杂交瘤细胞株及其应用，属于生物医学领域。本发明的杂交瘤细胞株为t-PAIC2#，已于2020年4月18日保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO：C202066，保藏地址为中国武汉，武汉大学。本发明还提供了由该杂交瘤细胞株分泌的tPAI-C单克隆抗体及tPAI-C单克隆抗体的应用。本发明杂交瘤细胞株可分泌对tPAI-C蛋白不同表位具有高亲和力的单克隆抗</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220701&DB=EPODOC&CC=CN&NR=114686442A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220701&DB=EPODOC&CC=CN&NR=114686442A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAN XIANGUI</creatorcontrib><creatorcontrib>WU PEITIAN</creatorcontrib><creatorcontrib>ZHUO YEBIN</creatorcontrib><creatorcontrib>LYU JINHUA</creatorcontrib><creatorcontrib>CHEN BO</creatorcontrib><title>Hybridoma cell strain and application thereof</title><description>The invention relates to a hybridoma cell strain and application thereof, and belongs to the field of biomedicine. The hybridoma cell strain disclosed by the invention is t-PAIC2 # and is preserved in China Center for Type Culture Collection on April 18, 2020, the preservation number is CCTCC NO: C202066, and the preservation address is Wuhan University, Wuhan, China. The invention also provides a tPAI-C monoclonal antibody secreted by the hybridoma cell strain and an application of the tPAI-C monoclonal antibody. The hybridoma cell strain disclosed by the invention can secrete monoclonal antibodies with high affinity to different epitopes of tPAI-C protein; when being used for detecting tPAI-C, the monoclonal antibody disclosed by the invention is not easily interfered by tPA and PAI-1 monomers and is high in accuracy.
本发明涉及一种杂交瘤细胞株及其应用，属于生物医学领域。本发明的杂交瘤细胞株为t-PAIC2#，已于2020年4月18日保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO：C202066，保藏地址为中国武汉，武汉大学。本发明还提供了由该杂交瘤细胞株分泌的tPAI-C单克隆抗体及tPAI-C单克隆抗体的应用。本发明杂交瘤细胞株可分泌对tPAI-C蛋白不同表位具有高亲和力的单克隆抗</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND1qEwqykzJz01USE7NyVEoLilKzMxTSMxLUUgsKMjJTE4syczPUyjJSC1KzU_jYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhiZmFmYmJkaOxsSoAQDLwSpA</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>TAN XIANGUI</creator><creator>WU PEITIAN</creator><creator>ZHUO YEBIN</creator><creator>LYU JINHUA</creator><creator>CHEN BO</creator><scope>EVB</scope></search><sort><creationdate>20220701</creationdate><title>Hybridoma cell strain and application thereof</title><author>TAN XIANGUI ; WU PEITIAN ; ZHUO YEBIN ; LYU JINHUA ; CHEN BO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114686442A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TAN XIANGUI</creatorcontrib><creatorcontrib>WU PEITIAN</creatorcontrib><creatorcontrib>ZHUO YEBIN</creatorcontrib><creatorcontrib>LYU JINHUA</creatorcontrib><creatorcontrib>CHEN BO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAN XIANGUI</au><au>WU PEITIAN</au><au>ZHUO YEBIN</au><au>LYU JINHUA</au><au>CHEN BO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hybridoma cell strain and application thereof</title><date>2022-07-01</date><risdate>2022</risdate><abstract>The invention relates to a hybridoma cell strain and application thereof, and belongs to the field of biomedicine. The hybridoma cell strain disclosed by the invention is t-PAIC2 # and is preserved in China Center for Type Culture Collection on April 18, 2020, the preservation number is CCTCC NO: C202066, and the preservation address is Wuhan University, Wuhan, China. The invention also provides a tPAI-C monoclonal antibody secreted by the hybridoma cell strain and an application of the tPAI-C monoclonal antibody. The hybridoma cell strain disclosed by the invention can secrete monoclonal antibodies with high affinity to different epitopes of tPAI-C protein; when being used for detecting tPAI-C, the monoclonal antibody disclosed by the invention is not easily interfered by tPA and PAI-1 monomers and is high in accuracy.
本发明涉及一种杂交瘤细胞株及其应用，属于生物医学领域。本发明的杂交瘤细胞株为t-PAIC2#，已于2020年4月18日保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO：C202066，保藏地址为中国武汉，武汉大学。本发明还提供了由该杂交瘤细胞株分泌的tPAI-C单克隆抗体及tPAI-C单克隆抗体的应用。本发明杂交瘤细胞株可分泌对tPAI-C蛋白不同表位具有高亲和力的单克隆抗</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | Hybridoma cell strain and application thereof |
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